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Perit Dial Int 28(Supplement_5): 16-20
2008
© 2008 International Society for Peritoneal Dialysis
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Articles

HOW CAN GENETIC ADVANCES IMPACT ON EXPERIMENTAL MODELS OF ENCAPSULATING PERITONEAL SCLEROSIS?

Angela M. Summers1, Catherine M. Hoff2 and Nicholas Topley3

Manchester Royal Infirmary,1 Manchester, United Kingdom; Baxter Healthcare,2 McGaw Park, Illinois, USA; School of Medicine,3 Cardiff University, Wales, United Kingdom

Correspondence to: A.M. Summers, Renal Research, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL United Kingdom. angela.summers{at}cmmc.nhs.uk

In this review we discuss how animal models have contributed to the understanding of pathological pathways that may be involved in the development of encapsulating peritoneal sclerosis. We review the various interventional procedures that, so far, have ameliorated disease progression in animals. Reviewing advancements in molecular biology and genetic technologies, we discuss how future experimental models may impact our understanding of the pathogenesis and treatment of this rare but complex disease.

KEY WORDS: Experimental; genetics; peritoneal sclerosis.






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